Search details
1.
A Physiological-Based Pharmacokinetic Model Embedded with a Target-Mediated Drug Disposition Mechanism Can Characterize Single-Dose Warfarin Pharmacokinetic Profiles in Subjects with Various CYP2C9 Genotypes under Different Cotreatments.
Drug Metab Dispos
; 51(2): 257-267, 2023 02.
Article
in English
| MEDLINE | ID: mdl-36379708
2.
Diverse Drug Classes Partition into Human Sweat: Implications for Both Sweat Fundamentals and for Therapeutic Drug Monitoring.
Ther Drug Monit
; 45(6): 731-742, 2023 12 01.
Article
in English
| MEDLINE | ID: mdl-37253460
3.
Pharmacokinetic Modeling of Warfarin ÐI - Model-based Analysis of Warfarin Metabolites following Warfarin Administered either Alone or Together with Fluconazole or Rifampin.
Drug Metab Dispos
; 2022 Jul 07.
Article
in English
| MEDLINE | ID: mdl-35798368
4.
Pharmacokinetic Modeling of Warfarin Ð - Model-based Analysis of Warfarin Enantiomers with a Target Mediated Drug Disposition Model Reveals CYP2C9 Genotype-dependent Drug-drug Interactions of S-Warfarin.
Drug Metab Dispos
; 2022 Jul 07.
Article
in English
| MEDLINE | ID: mdl-35798369
5.
Immobilized Cytochrome P450 for Monitoring of P450-P450 Interactions and Metabolism.
Drug Metab Dispos
; 44(5): 741-9, 2016 May.
Article
in English
| MEDLINE | ID: mdl-26961240
6.
Interindividual Variability in Cytochrome P450-Mediated Drug Metabolism.
Drug Metab Dispos
; 44(3): 343-51, 2016 Mar.
Article
in English
| MEDLINE | ID: mdl-26681736
7.
Nanoscale electron transport measurements of immobilized cytochrome P450 proteins.
Nanotechnology
; 26(15): 155102, 2015 Apr 17.
Article
in English
| MEDLINE | ID: mdl-25804257
8.
Altered CYP2C9 activity following modulation of CYP3A4 levels in human hepatocytes: an example of protein-protein interactions.
Drug Metab Dispos
; 42(11): 1940-6, 2014 Nov.
Article
in English
| MEDLINE | ID: mdl-25157098
9.
Measurement of electron transfer through cytochrome P450 protein on nanopillars and the effect of bound substrates.
J Am Chem Soc
; 135(10): 3834-40, 2013 Mar 13.
Article
in English
| MEDLINE | ID: mdl-23427827
10.
Effect of P450 oxidoreductase variants on the metabolism of model substrates mediated by CYP2C9.1, CYP2C9.2, and CYP2C9.3.
Pharmacogenet Genomics
; 22(8): 590-7, 2012 Aug.
Article
in English
| MEDLINE | ID: mdl-22547083
11.
Development of an in vitro system with human liver microsomes for phenotyping of CYP2C9 genetic polymorphisms with a mechanism-based inactivator.
Drug Metab Dispos
; 40(4): 836-42, 2012 Apr.
Article
in English
| MEDLINE | ID: mdl-22205778
12.
Localized delivery of chemotherapy to the cervix for radiosensitization.
Gynecol Oncol
; 127(1): 121-5, 2012 Oct.
Article
in English
| MEDLINE | ID: mdl-22796462
13.
Selective filling of nanowells in nanowell arrays fabricated using polystyrene nanosphere lithography with cytochrome P450 enzymes.
Nanotechnology
; 23(38): 385101, 2012 Sep 28.
Article
in English
| MEDLINE | ID: mdl-22947619
14.
Correlation between bilirubin glucuronidation and estradiol-3-gluronidation in the presence of model UDP-glucuronosyltransferase 1A1 substrates/inhibitors.
Drug Metab Dispos
; 39(2): 322-9, 2011 Feb.
Article
in English
| MEDLINE | ID: mdl-21030469
15.
The deaminated metabolite of gemcitabine, 2',2'-difluorodeoxyuridine, modulates the rate of gemcitabine transport and intracellular phosphorylation via deoxycytidine kinase.
Drug Metab Dispos
; 39(11): 2013-6, 2011 Nov.
Article
in English
| MEDLINE | ID: mdl-21832002
16.
Fundamentals of Enzyme Kinetics: Michaelis-Menten and Non-Michaelis-Type (Atypical) Enzyme Kinetics.
Methods Mol Biol
; 2342: 3-27, 2021.
Article
in English
| MEDLINE | ID: mdl-34272689
17.
Case Study 4: Application of Basic Enzyme Kinetics to Metabolism Studies-Real-Life Examples.
Methods Mol Biol
; 2342: 665-684, 2021.
Article
in English
| MEDLINE | ID: mdl-34272711
18.
Effects of genetic variants of human P450 oxidoreductase on catalysis by CYP2D6 in vitro.
Pharmacogenet Genomics
; 20(11): 677-86, 2010 Nov.
Article
in English
| MEDLINE | ID: mdl-20940534
19.
Bilirubin glucuronidation revisited: proper assay conditions to estimate enzyme kinetics with recombinant UGT1A1.
Drug Metab Dispos
; 38(11): 1907-11, 2010 Nov.
Article
in English
| MEDLINE | ID: mdl-20668247
20.
Glucuronidation of dihydrotestosterone and trans-androsterone by recombinant UDP-glucuronosyltransferase (UGT) 1A4: evidence for multiple UGT1A4 aglycone binding sites.
Drug Metab Dispos
; 38(3): 431-40, 2010 Mar.
Article
in English
| MEDLINE | ID: mdl-20007295